The sixth international symposium on “large TPCs for low-energy rare event detection” will be held in Paris on the 17th-19th of December 2012. The purpose of the meeting is an extensive discussion of present and future projects using a large TPC for low energy, low background detection of rare events (low-energy neutrinos, double beta decay, dark matter, solar axions). There is an increasing number of experiments using or planning to use very large gaseous or liquid TPCs.… A common feature of the detection scheme will be the measurement of the energy and direction of low energy recoils. The use of a new generation of gaseous micropattern detectors seems to be a promising way to reach this goal. A two and a half day symposium will be held in Paris, at the amphi Buffon near the National Library, on December 17, 18, 19, 2012. The physics and the present status of dark matter search, axion search and neutrino studies will be reviewed, in the light of recent LHC results, together with discussions on evolving technologies relevant to these searches.