We construct a noncommutative version of a general renormalizable SO(10) GUT with Higgses in the 210, 126¯, 45, 10 and 120 irreps of SO(10) and a Peccei-Quinn symmetry. Thus, we formulate the noncommutative counterpart of a nonsupersymmetric SO(10) GUT which has recently been shown to be consistent with all the physics below MGUT. The simplicity of our construction—the simplicity of the Yukawa terms, in particular—stems from the fact that the Higgses of our GUT can be viewed as elements of the Clifford algebra Cl10(C); elements on which the SO(10) gauge transformations act by conjugation. The noncommutative GUT we build contains tree-level interactions among different Higgs species that are absent in their ordinary counterpart as they are forbidden by SO(10) and Lorentz invariance. The existence of these interactions helps to clearly distinguish noncommutative Minkowski space-time from ordinary Minkowski space-time.