Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam

doi:10.2172/1420958

Title: Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam

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Abstract

The combination of fast neutron therapy and boron neutron capture therapy is currently under investigation at several fast neutron therapy centers worldwide. This treatment method, termed boron neutron capture enhanced fast neutron therapy (BNCEFNT) utilizes a boron containing drug to selectively increase the dose to the target tumor. BNCEFNT may be useful in the treatment of some radioresistant brain tumors, such as glioblastoma multiforme. A neutron therapy beam for boron neutron capture enhanced fast neutron therapy has been developed for the existing Fermilab Neutron Therapy Facility. This beam produces a significant dose enhancement due to the the boron neutron capture reaction. The beam was developed by designing a filter and collimator system using the Monte Carlo radiation transport code, MCNPX. The MCNPX code was benchmarked against depth-dose measurements of the standard treatment beam. The new BNCEFNT beam is filtered with 18.3-cm of low carbon steel and is collimated with steel. Measurements of the dose enhancement of the new BNCEFNT beam were performed with paired tissue equivalent ion chambers. One of the ion chambers has boron incorporated in the wall of the chamber to measure the dose due to boron neutron capture. The measured boron dose enhancement of the BNCEFNT beammore »« less

Authors:

Sweezy, Jeremy Ed ^[1]

Georgia Tech

Publication Date:: Tue Jan 01 00:00:00 EST 2002

Research Org.:: Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

Sponsoring Org.:: USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25)

OSTI Identifier:: 1420958

Report Number(s):: FERMILAB-THESIS-2002-05; UMI-30-46938
589345

DOE Contract Number:: AC02-07CH11359

Resource Type:: Thesis/Dissertation

Country of Publication:: United States

Language:: English

Subject:: 43 PARTICLE ACCELERATORS

Citation Formats


                    Sweezy, Jeremy Ed. Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam.  United States: N. p., 2002. 
        Web.  doi:10.2172/1420958.

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                    Sweezy, Jeremy Ed. Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam.  United States.  doi:10.2172/1420958.

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                    Sweezy, Jeremy Ed. Tue .  
        "Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam".  United States.  doi:10.2172/1420958.  https://www.osti.gov/servlets/purl/1420958.

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@article{osti_1420958,

  title        = {Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam},

  author       = {Sweezy, Jeremy Ed},

  abstractNote = {The combination of fast neutron therapy and boron neutron capture therapy is currently under investigation at several fast neutron therapy centers worldwide. This treatment method, termed boron neutron capture enhanced fast neutron therapy (BNCEFNT) utilizes a boron containing drug to selectively increase the dose to the target tumor. BNCEFNT may be useful in the treatment of some radioresistant brain tumors, such as glioblastoma multiforme. A neutron therapy beam for boron neutron capture enhanced fast neutron therapy has been developed for the existing Fermilab Neutron Therapy Facility. This beam produces a significant dose enhancement due to the the boron neutron capture reaction. The beam was developed by designing a filter and collimator system using the Monte Carlo radiation transport code, MCNPX. The MCNPX code was benchmarked against depth-dose measurements of the standard treatment beam. The new BNCEFNT beam is filtered with 18.3-cm of low carbon steel and is collimated with steel. Measurements of the dose enhancement of the new BNCEFNT beam were performed with paired tissue equivalent ion chambers. One of the ion chambers has boron incorporated in the wall of the chamber to measure the dose due to boron neutron capture. The measured boron dose enhancement of the BNCEFNT beam is (16.3 ± 2.6)% per 100-ppm 10B for a 20-cm diameter beam and (10.0 ± 1.6)% per 100-ppm 10B for a 10-cm diameter beam. The dose rate of the new beam is reduced to 4.4% of the dose rate of the standard treatment beam. xxi A conceptual design that overcomes the reduced dose rate is also presented. This design uses a tungsten collimator placed near the patient, with a 1.5-cm tungsten filter just upstream of the collimator. Using graphite moderation of neutrons around the patient a percent dose enhancement of 15% can be attained with good collimation, for field sizes as small as 5 × 5 cm2 , and without a reduction in dose rate.},

  doi          = {10.2172/1420958},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 01 00:00:00 EST 2002},

  month        = {Tue Jan 01 00:00:00 EST 2002}

}

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DOI: 10.2172/1420958

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