Nanoscale nuclear magnetic resonance with chemical resolution

Aslam, Nabeel; Pfender, Matthias; Neumann, Philipp; Reuter, Rolf; Zappe, Andrea; Fávaro de Oliveira, Felipe; Denisenko, Andrej; Sumiya, Hitoshi; Onoda, Shinobu; Isoya, Junichi

doi:10.1126/science.aam8697

Nanoscale nuclear magnetic resonance with chemical resolution

Jul 7, 2017

Published in:

Science 357 (2017) 6346, aam8697

Published: Jul 7, 2017

DOI:

10.1126/science.aam8697

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Abstract: (American Association for the Advancement of Science)

Nuclear magnetic resonance (NMR) spectroscopy is a key analytical technique in chemistry, biology, and medicine. However, conventional NMR spectroscopy requires an at least nanoliter-sized sample volume to achieve sufficient signal. We combined the use of a quantum memory and high magnetic fields with a dedicated quantum sensor based on nitrogen vacancy centers in diamond to achieve chemical shift resolution in 1H and 19F NMR spectroscopy of 20-zeptoliter sample volumes. We demonstrate the application of NMR pulse sequences to achieve homonuclear decoupling and spin diffusion measurements. The best measured NMR linewidth of a liquid sample was ~1 part per million, mainly limited by molecular diffusion. To mitigate the influence of diffusion, we performed high-resolution solid-state NMR by applying homonuclear decoupling and achieved a 20-fold narrowing of the NMR linewidth.

References(48)

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[1]

Two‐dimensional spectroscopy. Application to nuclear magnetic resonance

W.P. Aue
,
E. Bartholdi
,
R.R. Ernst

- J.Chem.Phys. 64 (1976) 2229-2246
•
DOI:
- 10.1063/1.432450

[2]

Three-dimensional NMR spectroscopy of a protein in solution

H. Oschkinat
,
C. Griesinger
,
P.J. Kraulis
,
O.W. Sørensen
,
R.R. Ernst

et al.

- Nature 332 (1988) 374-376
•
DOI:
- 10.1038/332374a0

[3]

Nat. Struct. Mol. Biol. 8, 923-925

K. Wüthrich

•
DOI:
- 10.1038/nsb1101-923

[4]

Image formation by induced local interactions: Examples employing nuclear magnetic resonance

P.C. Lauterbur

- Nature 242 (1973) 190-191
•
DOI:
- 10.1038/242190a0

[5]

Some preliminary observations on the proton magnetic resonance in biologic samples. Acta Radiol. 43, 469-476

E. Odeblad
,
G. Lindstrom

•
DOI:
- 10.3109/00016925509172514

[6]

Y. Gossuin
,
A. Hocq
,
P. Gillis
,
Q.L. Vuong

- J.Phys.D 43 (2010) 213001
•
DOI:
- 10.1088/0022-3727/43/21/213001

[7]

Small-volume nuclear magnetic resonance spectroscopy. Annu. Rev. Anal. Chem. (Palo Alto, Calif.) 4, 227-249

R.M. Fratila
,
A.H. Velders

•
DOI:
- 10.1146/annurev-anchem-061010-114024

[8]

Nanoscale magnetic resonance imaging

C.L. Degen
,
M. Poggio
,
H.J. Mamin
,
C.T. Rettner
,
D. Rugar

- Proc.Nat.Acad.Sci. 106 (2009) 1313-1317
•
DOI:
- 10.1073/pnas.0812068106

[9]

SQUID-detected in vivo MRI at microtesla magnetic fields

M. Mossle
,
W.R. Myers
,
S.-K. Lee
,
N. Kelso
,
M. Hatridge

et al.

- IEEE Trans.Appl.Supercond. 15 (2005) 757-760
•
DOI:
- 10.1109/TASC.2005.850043

[10]

Optical detection of liquid-state NMR

I.M. Savukov
,
S.-K. Lee
,
M.V. Romalis

- Nature 442 (2006) 1021-1024
•
DOI:
- 10.1038/nature05088

[11]

Magnetic resonance imaging with an optical atomic magnetometer

S. Xu
,
V.V. Yashchuk
,
M.H. Donaldson
,
S.M. Rochester
,
D. Budker

et al.

- Proc.Nat.Acad.Sci. 103 (2006) 12668-12671
•
DOI:
- 10.1073/pnas.0605396103

[12]

External high-quality-factor resonator tunes up nuclear magnetic resonance

M. Suefke
,
A. Liebisch
,
B. Blümich
,
S. Appelt

- Nature Phys. 11 (2015) 767-771
•
DOI:
- 10.1038/nphys3382

[13]

Nanoscale Nuclear Magnetic Resonance with a Nitrogen-Vacancy Spin Sensor

et al.

- Science 339 (2013) 6119, 1231540
•
DOI:
- 10.1126/science.1231540

[14]

Nuclear Magnetic Resonance Spectroscopy on a (5-Nanometer)3 Sample Volume

et al.

- Science 339 (2013) 6119, 1231675
•
DOI:
- 10.1126/science.1231675

[15]

Magnetic resonance spectroscopy of an atomically thin material using a single-spin qubit

I. Lovchinsky
,
J.D. Sanchez-Yamagishi
,
E.K. Urbach
,
S. Choi
,
S. Fang

et al.

- Science 355 (2017) 503-507
•
DOI:
- 10.1126/science.aal2538

[16]

Nanoscale nuclear magnetic imaging with chemical contrast

T. Häberle
,
D. Schmid-Lorch
,
F. Reinhard
,
J. Wrachtrup

- Nature Nanotech. 10 (2015) 125-128
•
DOI:
- 10.1038/nnano.2014.299

[17]

Proton magnetic resonance imaging using a nitrogen-vacancy spin sensor

D. Rugar
,
H.J. Mamin
,
M.H. Sherwood
,
M. Kim
,
C.T. Rettner

et al.

- Nature Nanotech. 10 (2015) 120-124
•
DOI:
- 10.1038/nnano.2014.288

[18]

Nanoscale NMR spectroscopy and imaging of multiple nuclear species

S.J. DeVience
,
L.M. Pham
,
I. Lovchinsky
,
A.O. Sushkov
,
N. Bar-Gill

et al.

- Nature Nanotech. 10 (2015) 129-134
•
DOI:
- 10.1038/nnano.2014.313

[19]

Probing molecular dynamics at the nanoscale via an individual paramagnetic centre

T. Staudacher
,
N. Raatz
,
S. Pezzagna
,
J. Meijer
,
F. Reinhard

et al.

- Nature Commun. 6 (2015) 8527
•
DOI:
- 10.1038/ncomms9527

[20]

Towards chemical structure resolution with nanoscale nuclear magnetic resonance spectroscopy

X. Kong
,
A. Stark
,
J. Du
,
L.P. McGuinness
,
F. Jelezko

- Phys.Rev.Applied 4 (2015) 024004
•
DOI:
- 10.1103/PhysRevApplied.4.024004

[21]

Single spin optically detected magnetic resonance with 60-90 GHz (E-band) microwave resonators

N. Aslam
,
M. Pfender
,
R. Stöhr
,
P. Neumann
,
M. Scheffler

et al.

- Rev.Sci.Instrum. 86 (2015) 064704
•
DOI:
- 10.1063/1.4922664

[22]

Enhancing quantum sensing sensitivity by a quantum memory

et al.

- Nature Commun. 7 (2016) 1, 12279
•
DOI:
- 10.1038/ncomms12279

[23]

Nonvolatile quantum memory enables sensor unlimited nanoscale spectroscopy of finite quantum systems

M. Pfender

•
e-Print:
- 1610.05675

[24]

Ultralong spin coherence time in isotopically engineered diamond

et al.

- Nature Materials 8 (2009) 5, 383-387
•
DOI:
- 10.1038/nmat2420

[25]

NMR technique for determining the depth of shallow nitrogen-vacancy centers in diamond

L.M. Pham
,
S.J. DeVience
,
F. Casola
,
I. Lovchinsky
,
A.O. Sushkov

et al.

- Phys.Rev.B 93 (2016) 045425
•
DOI:
- 10.1103/PhysRevB.93.045425

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