Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions
- Caterina Monini(),
- Gersende Alphonse(),
- Claire Rodriguez-Lafrasse(),
- Étienne Testa(),
- Michaël Beuve()
5 pages
Published in:
- Phys.Imag.Rad.Oncol. 12 (2019) 17-21
- Published: Oct, 2019
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Abstract: (submitter)
The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV), the Microdosimetric Kinetic Model (MKM) and the NanOx model for HSG, V79 and CHO-K1 cells in response to monoenergetic irradiations. Although the LEM IV and the MKM predictions accurately reproduced the trend observed in the data, NanOx yielded a better agreement than the other models for more irradiation configurations. Its estimator was indeed the lowest for three over seven considered cases.References(0)
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